Proteins play a central role in biology from immune recognition to brain activity. While major advances in machine learning have improved our ability to predict protein structure from sequence, determining protein function from structure remains a major challenge. Here, we introduce Holographic Convolutional Neural Network (H-CNN) for proteins, which is a physically motivated machine learning approach to model amino acid preferences in protein structures. H-CNN reflects physical interactions in a protein structure and recapitulates the functional information stored in evolutionary data. H-CNN accurately predicts the impact of mutations on protein function, including stability and binding of protein complexes. Our interpretable computational model for protein structure-function maps could guide design of novel proteins with desired function.

左心室（LV）功能是心脏病患者的患者管理，结局和长期存活方面的重要因素。最近发表的心力衰竭临床指南认识到，仅依赖一种心脏功能（LV射血分数）作为诊断和治疗分层生物标志物的依赖是次优。基于AI的超声心动图分析的最新进展已在LV体积和LV射血分数的自动估计上显示出良好的结果。但是，从随时间变化的2D超声心动图摄取，可以通过从完整的心脏周期中估算功能性生物标志物来获得对心脏功能的更丰富的描述。在这项工作中，我们首次提出了一种基于全心脏周期分割的2D超声心动图的AI方法，用于从2D超声心动图中得出高级生物标志物。这些生物标志物将允许临床医生获得健康和疾病中心脏的丰富图片。 AI模型基于“ NN-UNET”框架，并使用四个不同的数据库进行了训练和测试。结果表明，手动分析和自动分析之间的一致性很高，并展示了晚期收缩期和舒张期生物标志物在患者分层中的潜力。最后，对于50例病例的子集，我们在超声心动图和CMR的临床生物标志物之间进行了相关分析，我们在两种方式之间表现出了极好的一致性。

在本文中，我们为Pavlovian信号传达的多方面的研究 - 一个过程中学到的一个过程，一个代理商通过另一个代理商通知决策的时间扩展预测。信令紧密连接到时间和时间。在生成和接收信号的服务中，已知人类和其他动物代表时间，确定自过去事件以来的时间，预测到未来刺激的时间，并且都识别和生成展开时间的模式。我们调查通过引入部分可观察到的决策域来对学习代理之间的影响和信令在我们称之为霜冻空心的情况下如何影响学习代理之间的影响和信令。在该域中，预测学习代理和加强学习代理被耦合到两部分决策系统，该系统可以在避免时间条件危险时获取稀疏奖励。我们评估了两个域变型：机器代理在七态线性步行中交互，以及虚拟现实环境中的人机交互。我们的结果展示了帕夫洛维亚信号传导的学习速度，对药剂 - 代理协调具有不同时间表示（并且不）的影响，以及颞次锯齿对药剂和人毒剂相互作用的影响方式不同。作为主要贡献，我们将Pavlovian信号传导为固定信号范例与两个代理之间完全自适应通信学习之间的天然桥梁。我们进一步展示了如何从固定的信令过程计算地构建该自适应信令处理，其特征在于，通过快速的连续预测学习和对接收信号的性质的最小限制。因此，我们的结果表明了加固学习代理之间的沟通学习的可行建设者的途径。

在自主驾驶系统中，感知 - 来自环境的特征和物体的识别 - 至关重要。在自主赛车中，高速和小幅度的距离需要快速准确的检测系统。在比赛期间，天气可能会突然变化，导致感知的显着降解，导致操作效果无效。为了改善恶劣天气的检测，基于深度学习的模型通常需要在这种条件下捕获的广泛数据集 - 这是一种繁琐，费力和昂贵的过程。然而，最新的Conscangan架构的发展允许在多种天气条件下合成高度现实的场景。为此，我们介绍了一种在自主赛车中使用合成的不利条件数据集（使用Cyclegan产生）来提高五个最先进的探测器的性能，平均为42.7和4.4地图百分比点分别存在夜间条件和液滴。此外，我们对五个对象探测器进行了比较分析 - 识别探测器的最佳配对和在挑战条件下自主赛车中使用的培训数据。

作为自治车辆和自主赛车的竞争程度，所以需要更快，更准确的探测器。虽然我们的裸眼能够几乎立即提取上下文信息，但即使从远处地，图像分辨率和计算资源限制也使检测到较小的对象（即占用输入图像中小像素区域的对象）机器的真正具有挑战性的任务和一个广泛的研究领域。本研究探讨了如何修改流行的yolov5对象检测器以改善其在检测较小物体时的性能，具有自主赛车的特定应用。为实现这一目标，我们调查如何更换模型的某些结构元素（以及它们的连接和其他参数）可以影响性能和推理时间。在这样做时，我们提出了一系列模型，在不同的尺度上，我们命名为“YOLO-Z”，当时在50％iou的较小物体时，在地图上显示出高达6.9％的提高，以仅仅a与原始yolov5相比，推理时间增加3ms。我们的目标是为未来的研究提供调整流行检测器的可能性，例如YOLOV5以解决特定任务，并提供关于具体变化如何影响小对象检测的洞察。应用于自动车辆的更广泛背景的这种发现可以增加这些系统可用的上下文信息的量。

人工智能系统越来越涉及持续学习，以实现在系统培训期间不遇到的一般情况下的灵活性。与自治系统的人类互动广泛研究，但在系统积极学习的同时，研究发生了迄今为止发生的互动，并且可以在几分钟内明显改变其行为。在这项试验研究中，我们调查如何在代理商发展能力时如何发展人类和不断学习的预测代理人之间的互动。此外，我们可以比较两个不同的代理架构来评估代理设计中的代表性选择如何影响人工代理交互。我们开发虚拟现实环境和基于时间的预测任务，其中从增强学习（RL）算法增强人类预测中学到的预测。我们评估参与者在此任务中的性能和行为如何在代理类型中不同，使用定量和定性分析。我们的研究结果表明，系统的人类信任可能受到与代理人的早期互动的影响，并且反过来的信任会影响战略行为，但试点研究的限制排除了任何结论的声明。我们将信任作为互动的关键特征，以考虑基于RL的技术在考虑基于RL的技术时，并对这项研究进行了几项建议，以准备更大规模的调查。本文的视频摘要可以在https://youtu.be/ovyjdnbqtwq找到。

The recent increase in public and academic interest in preserving biodiversity has led to the growth of the field of conservation technology. This field involves designing and constructing tools that utilize technology to aid in the conservation of wildlife. In this article, we will use case studies to demonstrate the importance of designing conservation tools with human-wildlife interaction in mind and provide a framework for creating successful tools. These case studies include a range of complexities, from simple cat collars to machine learning and game theory methodologies. Our goal is to introduce and inform current and future researchers in the field of conservation technology and provide references for educating the next generation of conservation technologists. Conservation technology not only has the potential to benefit biodiversity but also has broader impacts on fields such as sustainability and environmental protection. By using innovative technologies to address conservation challenges, we can find more effective and efficient solutions to protect and preserve our planet's resources.

A Digital Twin (DT) is a simulation of a physical system that provides information to make decisions that add economic, social or commercial value. The behaviour of a physical system changes over time, a DT must therefore be continually updated with data from the physical systems to reflect its changing behaviour. For resource-constrained systems, updating a DT is non-trivial because of challenges such as on-board learning and the off-board data transfer. This paper presents a framework for updating data-driven DTs of resource-constrained systems geared towards system health monitoring. The proposed solution consists of: (1) an on-board system running a light-weight DT allowing the prioritisation and parsimonious transfer of data generated by the physical system; and (2) off-board robust updating of the DT and detection of anomalous behaviours. Two case studies are considered using a production gas turbine engine system to demonstrate the digital representation accuracy for real-world, time-varying physical systems.

We introduce Argoverse 2 (AV2) - a collection of three datasets for perception and forecasting research in the self-driving domain. The annotated Sensor Dataset contains 1,000 sequences of multimodal data, encompassing high-resolution imagery from seven ring cameras, and two stereo cameras in addition to lidar point clouds, and 6-DOF map-aligned pose. Sequences contain 3D cuboid annotations for 26 object categories, all of which are sufficiently-sampled to support training and evaluation of 3D perception models. The Lidar Dataset contains 20,000 sequences of unlabeled lidar point clouds and map-aligned pose. This dataset is the largest ever collection of lidar sensor data and supports self-supervised learning and the emerging task of point cloud forecasting. Finally, the Motion Forecasting Dataset contains 250,000 scenarios mined for interesting and challenging interactions between the autonomous vehicle and other actors in each local scene. Models are tasked with the prediction of future motion for "scored actors" in each scenario and are provided with track histories that capture object location, heading, velocity, and category. In all three datasets, each scenario contains its own HD Map with 3D lane and crosswalk geometry - sourced from data captured in six distinct cities. We believe these datasets will support new and existing machine learning research problems in ways that existing datasets do not. All datasets are released under the CC BY-NC-SA 4.0 license.

We present a Machine Learning (ML) study case to illustrate the challenges of clinical translation for a real-time AI-empowered echocardiography system with data of ICU patients in LMICs. Such ML case study includes data preparation, curation and labelling from 2D Ultrasound videos of 31 ICU patients in LMICs and model selection, validation and deployment of three thinner neural networks to classify apical four-chamber view. Results of the ML heuristics showed the promising implementation, validation and application of thinner networks to classify 4CV with limited datasets. We conclude this work mentioning the need for (a) datasets to improve diversity of demographics, diseases, and (b) the need of further investigations of thinner models to be run and implemented in low-cost hardware to be clinically translated in the ICU in LMICs. The code and other resources to reproduce this work are available at https://github.com/vital-ultrasound/ai-assisted-echocardiography-for-low-resource-countries.